Programme to raise awareness in Catalonia about preventing the vertical transmission of Chagas disease

ISGlobal - ISGlobal - Fundación Mundo Sano and ELEA - Catalan Government

Programme to raise awareness in the Latin American community and among health professionals about the importance of screening pregnant women and newborns for Chagas disease.

Type of Project: Research & Translation

Type of Activity: Control & Prevention, Information, Education & Communication (IEC)

Changes in serologic markers, diastolic function markers and segmental contractility detected by echocardiography in Chagas disease following antiparasitic treatment

ISGlobal - International Health Department (Tropical Medicine Section), Cardiology Department, and Microbiology/Parasitology Departments at Hospital Clínic de Barcelona

A study of early diagnostic markers for Chagas heart disease and markers of treatment efficacy in Chagas disease.

Type of Project: Research & Translation

Type of Activity: Diagnóstico y/o biomarcadores

Paediatric dosage form of Benznidazole

DNDi - Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) - Centro de Chagas y Patologia Regional, Hospital Independencia, Santiago del Estero - Centro Nacional de Diagnóstico e Investigación de Endemo-epidemias (CeNDIE), Ministry of Health - CONICET-INGEBI - Fundación Mundo Sano and ELEA - Hospital de Niños de Jujuy - Hospital de Niños Ricardo Gutierrez - Hospital Público Materno Infantil – Salta - Instituto Nacional de Parasitología Dr M Fatala Chabén - Laboratorio ELEA - Laboratório Farmacêutico do Estado de Pernambuco (LAFEPE) - Ministério de Salud Província de Jujuy - Nucleus of Pharmaceutical and Cosmetics Development (NUDFAC) - University of Liverpool

DNDi intends to develop and make available an easily dispersible, simpler to administer, safer, age-adapted dosage for children under two years old.

Type of Project: Research & Translation

Type of Activity: Treatment

New Benznidazole Regimens / Combos

DNDi - Universidad Autónoma Juan Misael Saracho - Universidad Mayor de San Simón - Centre de Recerca en Salut Internacional de Barcelona (CRESIB) - Eisai Co. Ltd - FP Clinical Pharma - Ethel Feleder - Fundación Mundo Sano and ELEA - Instituto Nacional de Parasitología Dr M Fatala Chabén - LAT Research - National Council of Scientific and Technological Research (INGEBI/CONICET) - Nucleus of Pharmaceutical and Cosmetics Development (NUDFAC) - PhinC - Platform of Integral Care for Patients with Chagas Disease, Tarija and Cochabamba - CEADES

DNDi’s overall objectives are to develop new benznidazole monotherapy regimen for chronic Chagas disease and the development of a new benznidazole and E1224 combination treatment regimen for chronic Chagas disease.

Type of Project: Research & Translation

Type of Activity: Treatment

Lead Optimization Latin America - LOLA

DNDi - AbbVie - Centre for Drug Candidate Optimization (CDCO)/Monash University - Epichem - Griffith University (Eskitis) - iThemba - LMPH, University of Antwerp - LNBio - LSHTM - Novartis Institute for Tropical Diseases (NITD) - Pace University - Pfizer - Sandexis - TCG Life Sciences - Universidad de Campinas - WuXi AppTech

DNDi aims to establish a robust portfolio of drug discovery quality lead series for the three kinetoplastid diseases, among which is Chagas disease.

Type of Project: Research & Translation

Type of Activity: Treatment

Fexinidazole for Chagas

DNDi - Universidad Autónoma Juan Misael Saracho - Universidad Mayor de San Simón - ISGlobal - Cardiabase - CREAPHARMA - JSS Medical Research - Molecular Biology Laboratory (BioMol) - National Council of Scientific and Technological Research (INGEBI/CONICET) - PhinC - Platform of Integral Care for Patients with Chagas Disease, Tarija and Cochabamba - CEADES

DNDi objective is to evaluate fexinidazole for treatment of chronic Chagas disease and possibly provide treatment regimen alternative to nifurtimox and benznidazole.

Type of Project: Research & Translation

Type of Activity: Treatment

Deployment Project

DNDi - Instituto Nacional de Salud de Colombia - Los Angeles University - Programa Nacional de Colombia y Mexico (CENAPRECE) - RedChagas - UNAM

DNDi intends to demonstrate the feasibility of scaling up access to diagnosis and treatment for Chagas disease in specific contexts and diverse epidemiological profiles.

Type of Project: Research & Translation

Type of Activity: Treatment

Biomarkers

DNDi - Universidad Autónoma Juan Misael Saracho - Universidad Mayor de San Simón - ISGlobal - Instituto Nacional de Parasitología Dr M Fatala Chabén - McGill University - Médecins Sans Frontières (MSF) - National Council of Scientific and Technological Research (INGEBI/CONICET) - NHEPACHA network - Texas Biomedical Research Institute - Universidad Nacional San Martín, Buenos Aires - University Hospitals of Geneva - University of Georgia - University of Texas at El Paso

As a medium-term strategy, DNDi seeks to identify and evaluate new biological markers of therapeutic efficacy in chronic Chagas disease and to promote research.

Type of Project: Research & Translation

Type of Activity: Diagnóstico y/o biomarcadores, Treatment

Contributing to the global fight against Chagas disease by adapting the protocol-based model to the structures of the Bolivian National Health System to create an inclusive healthcare network

CEADES - ISGlobal - Bolivian National Chagas Control Programme - Universidad Autónoma Juan Misael Saracho - Universidad Mayor de San Simón - Corazónes Unidos por el Chagas - Agencia Española de Cooperación Internacional para el Desarrollo (AECID), a través de la Oficina Técnica de Cooperación en La Paz

To improve control of Chagas disease in Bolivia

Type of Project: Research & Translation

Type of Activity: Control & Prevention, Diagnóstico y/o biomarcadores, Information, Education & Communication (IEC), Treatment