Antiparasitic activity of synthetic peptides derived from the skin of amphibians against Malaria, Chagas and Leishmaniasis

CISeAL. Lugar: CISeAL, Pontificia Universidad Católica del Ecuador

Area of Activity: Diagnóstico y/o biomarcadores, Treatment
Type of Project: Research & Translation

This frog’s skin contains peptides of medical interest, some of them thought to have antiparasitic properties. By: Ailin Blasco

The project is executed by researchers from the Pontificia Universidad Católica del Ecuador, Ikiam and the Universidad San Francisco de Quito (USFQ) to evaluate the potential antiparasitic activity of at least five synthetic antimicrobial peptides from the skin of Ecuadorian amphibians, against Plasmodium falciparum, Trypanosoma cruzi and Mexican Leishmania, causal agents of malaria, Chagas disease and leishmaniasis, respectively. Preliminary information shows the antimicrobial capacity of these peptides, in combination with their low toxicity against human cells, which suggests that they will also be able to inhibit or control parasites, without causing adverse effects in infected people, and with a low probability of provoking resistance.

Team member of the laboratory (LICBA) in charge of extracting the peptides from the frog’s skin. By: Ailin Blasco